International cooperation and regional integration are vital for the development of science, technology and innovation systems in Latin America and the Caribbean. It is essential to build new spaces for cooperation that enhance the scientific and technological development of countries, favour exchanges of research professionals, promote the flow of knowledge and attract foreign direct investment (FDI) in innovation. There is also high potential in the development, strengthening and interlinking of Latin American and Caribbean capacities, both within the region and with other regions, which foster the creation of centres of excellence in research and development. The panel will address the challenges and opportunities that exist in the regional integration of science, technology and innovation systems, as well as the spaces that can be created to foster international cooperation in this area.