The digital revolution is transforming the economy and society increasingly rapidly. Widely available and uninterrupted connectivity has reached much of humanity thanks to the mass take-up of smartphones and the consequent access to information, social networks and audiovisual entertainment. The acceleration of technical progress in the digital realm has made the use of devices and applications employing cloud computing, big data analysis, blockchains or artificial intelligence routine. The technological revolution, combined with a change in the strategies of the companies at the forefront of digital technology use, has also led to the rise of global platforms. Digital technologies have played a key role in addressing the effects of the COVID-19 pandemic. However, the potential benefits from their use are clearly constrained by structural factors, such as limits on connectivity (access, use and speed), social inequalities, productive heterogeneity and low competitiveness, and restricted access to data and information management, among other factors. The panel will address the main opportunities and challenges for the countries of Latin America and the Caribbean, in order to contribute to the discussion and to action for the roll-out and use of digital technology and its appropriation, and to creation of digital solutions at national and regional level, to strengthen and support development processes.